Wiebke Arlt Selected Research

Virilism (Virilization)

1/2020	Reply to Flück et al.: Alternative androgen pathway biosynthesis drives fetal female virilization in P450 oxidoreductase deficiency.
10/2019	Alternative pathway androgen biosynthesis and human fetal female virilization.
7/2010	Concomitant mutations in the P450 oxidoreductase and androgen receptor genes presenting with 46,XY disordered sex development and androgenization at adrenarche.
3/2009	The adrenal cortex and sexual differentiation during early human development.
9/2007	Age-specific changes in sex steroid biosynthesis and sex development.
2/2007	Congenital adrenal hyperplasia and P450 oxidoreductase deficiency.
11/2004	A male twin infant with skull deformity and elevated neonatal 17-hydroxyprogesterone: a prismatic case of P450 oxidoreductase deficiency.
8/2004	Prenatal diagnosis of P450 oxidoreductase deficiency (ORD): a disorder causing low pregnancy estriol, maternal and fetal virilization, and the Antley-Bixler syndrome phenotype.

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Wiebke Arlt Research Topics

Disease

34	Congenital Adrenal Hyperplasia (Hyperplasia, Congenital Adrenal) 12/2022 - 06/2004
24	Adrenal Insufficiency (Adrenal Gland Hypofunction) 11/2021 - 09/2002
23	Neoplasms (Cancer) 03/2022 - 08/2010
16	Polycystic Ovary Syndrome (Syndrome, Stein-Leventhal) 12/2021 - 06/2003
13	Hypertension (High Blood Pressure) 03/2022 - 05/2010
13	Insulin Resistance 10/2019 - 08/2011
12	Addison Disease (Addison's Disease) 03/2021 - 05/2002
10	Prostatic Neoplasms (Prostate Cancer) 01/2022 - 02/2012
9	Adrenocortical Carcinoma 01/2021 - 01/2011
8	Adenoma (Adenomas) 01/2022 - 08/2016
8	Congenital adrenal hyperplasia due to 21 hydroxylase deficiency 01/2021 - 02/2007
8	Virilism (Virilization) 01/2020 - 08/2004
7	Type 2 Diabetes Mellitus (MODY) 03/2022 - 08/2016
7	Cushing Syndrome 03/2022 - 02/2015
7	Infections 05/2021 - 10/2009
7	Obesity 01/2021 - 11/2004
7	Sepsis (Septicemia) 01/2020 - 07/2006
7	Antley-Bixler Syndrome Phenotype 12/2010 - 03/2004
6	Adrenal incidentaloma 01/2022 - 12/2011
6	Critical Illness (Critically Ill) 01/2018 - 06/2008
6	Disorders of Sex Development (Intersexuality) 09/2014 - 06/2004
5	Wounds and Injuries (Trauma) 01/2021 - 07/2006
5	Hyperandrogenism 01/2021 - 06/2003
5	Cortisone reductase deficiency 08/2011 - 08/2003
4	Pseudotumor Cerebri (Idiopathic Intracranial Hypertension) 01/2021 - 01/2019
4	Inflammation (Inflammations) 01/2021 - 01/2008
4	Non-alcoholic Fatty Liver Disease 01/2020 - 09/2017
4	Respiratory Distress Syndrome (Acute Respiratory Distress Syndrome) 12/2017 - 01/2008
4	Septic Shock (Toxic Shock Syndrome) 12/2017 - 07/2006
4	Hypogonadism (Hypergonadotropic Hypogonadism) 09/2017 - 06/2010
3	Anovulation 05/2021 - 05/2009
3	Hyperplasia 01/2021 - 04/2017
3	Neoplasm Metastasis (Metastasis) 11/2020 - 08/2016
3	Metabolic Diseases (Metabolic Disease) 01/2020 - 09/2017
3	Hyperaldosteronism (Conn Syndrome) 12/2018 - 04/2017
3	Hypopituitarism (Sheehan's Syndrome) 11/2015 - 08/2003
2	Menstruation Disturbances 12/2021 - 11/2017
2	COVID-19 05/2021 - 07/2020
2	Cardiovascular Diseases (Cardiovascular Disease) 05/2021 - 09/2017
2	Breast Neoplasms (Breast Cancer) 01/2021 - 03/2019
2	Overweight 01/2021 - 01/2019
2	Osteoporosis 10/2020 - 04/2017
2	Fever (Fevers) 07/2020 - 04/2013
2	Hypokalemia 08/2019 - 02/2012
2	Diabetes Mellitus 01/2019 - 12/2016
2	Dyslipidemias (Dyslipidemia) 01/2019 - 12/2016

Drug/Important Bio-Agent (IBA)

61	AndrogensIBA 01/2022 - 09/2002
43	GlucocorticoidsIBA 01/2021 - 09/2002
42	SteroidsIBA 03/2022 - 06/2004
41	Hydrocortisone (Cortisol)FDA LinkGeneric 12/2022 - 08/2003
17	Oxidoreductases (Dehydrogenase)IBA 01/2020 - 03/2004
15	Dehydroepiandrosterone (DHEA)IBA 01/2021 - 05/2002
14	Hormones (Hormone)IBA 01/2022 - 02/2002
13	EnzymesIBA 01/2021 - 03/2004
11	Testosterone (Sustanon)FDA Link 01/2020 - 08/2004
9	MineralocorticoidsIBA 10/2021 - 05/2003
9	Adrenocorticotropic Hormone (ACTH)FDA Link 02/2017 - 08/2003
8	Dexamethasone (Maxidex)FDA LinkGeneric 03/2022 - 06/2008
8	Adrenal Cortex Hormones (Corticosteroids)IBA 01/2018 - 06/2008
7	Androgen Receptors (Androgen Receptor)IBA 01/2022 - 07/2010
6	Glucose (Dextrose)FDA LinkGeneric 05/2021 - 03/2014
6	Steroid 21-Hydroxylase (21 Hydroxylase)IBA 11/2018 - 06/2004
4	Insulin (Novolin)FDA Link 03/2022 - 02/2015
4	abirateroneIBA 01/2022 - 02/2012
4	Steroid 17-alpha-Hydroxylase (17 alpha Hydroxylase)IBA 10/2021 - 03/2012
4	Biomarkers (Surrogate Marker)IBA 01/2021 - 10/2008
4	LipidsIBA 01/2021 - 02/2013
4	Cosyntropin (Cortrosyn)FDA LinkGeneric 01/2020 - 02/2012
4	Dehydroepiandrosterone SulfateIBA 01/2020 - 07/2006
4	Triglycerides (Triacylglycerol)IBA 10/2019 - 05/2010
4	Androstenedione (4 Androstene 3,17 dione)IBA 03/2019 - 03/2014
4	Mitotane (Lysodren)FDA Link 03/2018 - 06/2012
4	Steroid 11-beta-Hydroxylase (11 beta-Hydroxylase)IBA 04/2017 - 02/2010
4	Cytochrome P-450 Enzyme System (Cytochrome P450)IBA 03/2013 - 03/2004
3	Methylprednisolone FDA LinkGeneric 12/2017 - 06/2008
3	17-alpha-Hydroxyprogesterone (17 Hydroxyprogesterone)IBA 11/2017 - 11/2004
3	11-beta-Hydroxysteroid Dehydrogenase Type 1IBA 03/2011 - 08/2003
2	Glucocorticoid Receptors (Glucocorticoid Receptor)IBA 01/2022 - 01/2019
2	Mixed Function Oxygenases (Monooxygenases)IBA 10/2021 - 03/2013
2	2- (1- (5- (cyclohexylcarbamoyl)- 6- propylsulfanylpyridin- 2- yl)- 3- piperidyl)acetic acidIBA 01/2021 - 01/2020
2	Estrogens (Estrogen)FDA Link 01/2021 - 03/2011
2	CytokinesIBA 01/2021 - 05/2014
2	ReninIBA 01/2020 - 12/2012
2	SaltsIBA 01/2020 - 11/2017
2	NormetanephrineIBA 12/2019 - 03/2013
2	Messenger RNA (mRNA)IBA 10/2019 - 02/2017
2	Abiraterone AcetateIBA 08/2019 - 02/2012
2	Biological ProductsIBA 03/2019 - 03/2009
2	Proteins (Proteins, Gene)FDA Link 01/2019 - 01/2015
2	Sex Hormone-Binding GlobulinIBA 01/2019 - 01/2018
2	C-Reactive ProteinIBA 01/2019 - 12/2012
2	Mineralocorticoid Receptor AntagonistsIBA 12/2018 - 04/2017
2	AldosteroneIBA 12/2018 - 04/2017
2	ProlactinIBA 01/2018 - 11/2017

Therapy/Procedure

22	Therapeutics 03/2022 - 05/2003
9	Castration 01/2022 - 02/2012
6	Critical Care (Surgical Intensive Care) 01/2018 - 06/2008
5	Adrenalectomy 01/2021 - 12/2016
4	Ovariectomy (Oophorectomy) 09/2012 - 11/2004
2	Resuscitation 01/2021 - 04/2009